Feb 13, 2025
|
12:00pm - 1:00pm
Structural methods reveal IL-17 signalling principles
Type
Invited Speaker Seminar
Format
In-Person
Department/Unit
Department of Biochemistry, Department of Medical Biophysics, Department of Pharmacology & Toxicology
Speaker(s)
Dr. Nathanael Caveney
Abstract:
Interleukin-17 (IL-17) signalling plays a critical role in inflammation and disease, with IL-17 antagonists already in clinical use for conditions psoriasis. However, the structural basis of IL-17 receptor–cytokine interactions remain poorly understood. This talk explores recent structural biology advances that reveal key paradigms of IL-17 signalling. Using structural and biophysical approaches, we examine IL-17–receptor interactions, the role of IL-17RA as a receptor versus co-receptor, and implications for therapeutic development.
Location: McLennan Physical Laboratories, Room MP606
Poster: Nathanael Caveney_Feb13.pdf